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SCO7671 SCO7671 SCO7670 SCO7670 SCO7669 SCO7669 SCO6827 SCO6827 SCO0618 SCO0618 SCO7672 SCO7672 SCO4654 SCO4654 SCO1454 SCO1454 SCO1478 SCO1478 SCO4729 SCO4729 SCO5368 SCO5368
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO7671SC4C2.06c, possible transferase, len: 412 aa; similar to SW:BCSA_BACSU (EMBL:L77246) Bacillus subtilis putative chalcone synthase (EC 2.3.1.74) BcsA, 365 aa; fasta scores: opt: 353 z-score: 334.4 E(): 4.3e-11; 31.0% identity in 339 aa overlap. Contains 2x Pfam matches to entry PF00195 Chal_stil_synt, Chalcone and stilbene synthases and match to Prosite entry PS00196 Type-1 copper (blue) proteins signature. Also contains 9x degenerate repeat: GS. (412 aa)    
Predicted Functional Partners:
SCO7670
SC4C2.05c, conserved hypothetical protein, len: 171 aa; similar to TR:O06539 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical 19.0 kDa protein MTCI65.06c, 166 aa; fasta scores: opt: 697 z-score: 858.3 E(): 0; 62.4% identity in 165 aa overlap.
 
  
 0.990
SCO7669
SC4C2.04c, possible oxidoreductase, len: 343 aa; similar to TR:O06538 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical 36.3 kDa protein MTCI65.05c, 338 aa; fasta scores: opt: 1020 z-score: 1087.7 E(): 0; 50.7% identity in 339 aa overlap. Contains Pfam match to entry PF01360 Monooxygenase, Monooxygenase.
 
  
 0.984
SCO6827
SC4A9.04c, polyketide synthase, len: 2358 aa. Highly similar to many including: Stigmatella aurantiaca TR:AAF19813(EMBL:AF188287) polyketide synthase, MtAE, found within the Myxothiazol biosynthetic gene cluster (1947 aa), fasta scores opt: 2671 z-score: 2436.5 E():0 35.8% identity in 1770 aa overlap and Mycobacterium tuberculosis SW:PPSA_MYCTU(EMBL:Z74697) phenolpthiocerol synthesis polyketide synthase gene, PpsA (1876 aa), fasta scores opt: 2221 z-score: 2025.5 E(): 0 33.6% identity in 1761 aa overlap. Contains Prosite hits to PS00606 Beta-ketoacyl synthases active site and 2xPS00012 [...]
 
 
 0.877
SCO0618
SCF56.02, hypothetical protein, len: 461 aa; similar to various hypothetical proteins, e.g. TR:BAA86645 (EMBL:AB033763) Staphylococcus aureus hypothetical 49.4 kD protein, 442 aa; fasta scores: opt: 286 z-score: 318.4 E(): 2.3e-10; 26.6% identity in 466 aa overlap.
    
   0.851
SCO7672
SC4C2.07, possible integral membrane protein, len: 286 aa. Contains possible hydrophobic membrane spanning regions.
 
     0.845
SCO4654
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 0.813
SCO1454
SCL6.11c, possible amino oxidase, len: 565 aa; similar to C-terminal region of SW:TR2M_AGRVI (EMBL:M91609) Agrobacterium vitis tryptophan 2-monooxygenase (EC 1.13.12.3) IaaM (auxins biosynthesis), 723 aa; fasta scores: opt: 617 z-score: 725.3 E(): 5.6e-33; 30.9% identity in 557 aa overlap. Contains Pfam match to entry PF01593 Amino_oxidase, Flavin containing amine oxidase.
    
 
 0.803
SCO1478
Putative DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
    
  0.782
SCO4729
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
  0.773
SCO5368
ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
   
 0.765
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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